From flamingo dance to (desirable) drug discovery: a nature-inspired approach

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Sanchez Rodriguez, A (Author) Other; Perez Castillo, Y (Author) Other; Schurer, SC (Author) Other; Nicolotti, O (Author) Other; Mangiatordi, GF (Author) Other; Fernanda Borges (Author) FCUP; Natalia N D S Cordeiro (Author) FCUP; Tejera, E (Author) Other; Medina Franco, JL (Author) Other; Cruz Monteagudo, M (Author) Other

Journal

Title: Drug Discovery Today

Vol. 22

Pages: 1489-1502

ISSN: 1359-6446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 26 Citations

Scopus - 28 Citations

Other information

Authenticus ID: P-00N-5D8

DOI: 10.1016/j.drudis.2017.05.008

Abstract (EN): The therapeutic effects of drugs are well known to result from their interaction with multiple intracellular targets. Accordingly, the pharma industry is currently moving from a reductionist approach based on a 'one-target fixation' to a holistic multitarget approach. However, many drug discovery practices are still procedural abstractions resulting from the attempt to understand and address the action of biologically active compounds while preventing adverse effects. Here, we discuss how drug discovery can benefit from the principles of evolutionary biology and report two real-life case studies. We do so by focusing on the desirability principle, and its many features and applications, such as machine learning-based multicriteria virtual screening.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14