Prognostic factors in an exercised model of chemically-induced mammary cancer

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Antonieta Alvarado (Author) Other; Ana I. Faustino-Rocha (Author) Other; Rita Ferreira (Author) Other; Rafael Mendes (Author) Other; José Alberto Duarte (Author) FADEUP; Maria João Pires (Author) Other; Bruno Colaço (Author) Other; Paula A. Oliveira (Author) Other

Journal

Title: Anticancer Research

Vol. 36 No. 5

Pages: 2181-2188

ISSN: 0250-7005

Publisher: International Institute of Anticancer Research

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 7 Citations

Scientific classification

FOS: Social sciences

Other information

Authenticus ID: P-00K-FHV

Abstract (EN): Background/Aim: Estrogen receptor alpha ( ER alpha) and Ki-67 are strong prognostic and predictive markers in woman breast cancer. This study aimed to evaluate the immunoexpression of prognostic factor markers ER alpha, Ki-67 proliferation index (Ki-67 PI) and the mitotic activity index (MAI) in mammary tumors induced by 1-methyl-1-nitrosourea (MNU) in female Sprague-Dawley rats submitted to lifelong exercise training. Materials and Methods: Thirty female rats were injected with MNU and randomly divided into two groups: sedentary and exercised. Results: All neoplasms from both groups were ER alpha-positive with an H-score >= 20. Statistically significant differences were not found in the ER alpha H-score, Ki-67 PI and MAI between groups. The absolute value of ER alpha H-score was higher in the exercised group, while the Ki-67 PI and MAI were higher in the sedentary group. Conclusion: Tumors from the exercised group were less proliferative and more differentiated, suggesting that long-term exercise training had positive effects on mammary carcinogenesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8