Long-term exercise training prevents mammary tumorigenesis-induced muscle wasting in rats through the regulation of TWEAK signalling

• Type: Article in International Scientific Journal
• Date: 2017

Authors

A. I. Padrão (Author) Other; A. C. C. Figueira (Author) Other; A. I. Faustino‐Rocha (Author) Other; A. Gama (Author) Other; M. M. Loureiro (Author) Other; M. J. Neuparth (Author) Other; D. Moreira‐Gonçalves (Author) Other; R. Vitorino (Author) Other; F. Amado (Author) Other; L. L. Santos (Author) Other; P. A. Oliveira (Author) Other; J. A. Duarte (Author) FADEUP; R. Ferreira (Author) Other

Journal

Title: Acta Physiologica

Vol. 219

Pages: 803-813

ISSN: 1748-1708

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 19 Citations

Scientific classification

FOS: Social sciences ; Medical and Health sciences

Other information

Authenticus ID: P-00M-P13

DOI: 10.1111/apha.12721

Abstract (EN): AimExercise training has been suggested as a non-pharmacological approach to prevent skeletal muscle wasting and improve muscle function in cancer cachexia. However, little is known about the molecular mechanisms underlying such beneficial effect. In this study, we aimed to, firstly, examine the contribution of TWEAK signalling to cancer-induced skeletal muscle wasting and, secondly, evaluate whether long-term exercise alters TWEAK signalling and prevents muscle wasting. MethodsFemale Sprague-Dawley rats were randomly assigned to control and exercise groups. Fifteen animals from each group were exposed to N-Methyl-N-nitrosourea carcinogen. Animals in exercise groups were submitted to moderate treadmill exercise for 35weeks. After the experimental period, animals were killed and gastrocnemius muscles were harvested for morphological and biochemical analysis. ResultsWe verified that exercise training prevented tumour-induced TWEAK/NF-B signalling in skeletal muscle with a beneficial impact in fibre cross-sectional area and metabolism. Indeed, 35weeks of exercise training promoted the upregulation of PGC-1 and oxidative phosphorylation complexes. This exercise-induced muscle remodelling in tumour-bearing animals was associated with less malignant mammary lesions. ConclusionData support the benefits of an active lifestyle for the prevention of muscle wasting secondary to breast cancer, highlighting TWEAK/NF- B signalling as a potential therapeutic target for the preservation of muscle mass.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11