Thermodynamic study of nicotinamide, N-methylnicotinamide and N,N-dimethylnicotinamide: Vapour pressures, phase diagrams, and hydrogen bonds

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Almeida, ARRP (Author) FCUP; Oliveira, JASA (Author) Other; Manuel J S Monte (Author) FCUP

Journal

Title: Journal of Chemical Thermodynamics

Vol. 82

Pages: 108-115

ISSN: 0021-9614

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-00A-0CZ

DOI: 10.1016/j.jct.2014.11.001

Abstract (EN): Using the Knudsen-effusion method and/or a diaphragm manometer static method, the vapour pressures of the condensed phases (crystalline and liquid) of nicotinamide, N-methylnicotinamide and N, N-dimethylnicotinamide were measured, respectively, over the following temperatures ranges (341.2 to 433.7) K, (329.2 to 426.6) K and (308.2 to 370.5) K. The experimental results enabled the determination of the standard molar enthalpies, entropies and Gibbs free energies of sublimation and of vaporisation, at T = 298.15 K, as well as phase diagram representations of the (p, T) experimental results, including the triple point, for the three compounds studied. The temperatures and molar enthalpies of fusion were determined using differential scanning calorimetry and were compared with the values derived indirectly from the vapour pressure measurements. The enthalpy of the intermolecular hydrogen bonds N -H center dot center dot O present in crystalline N-methylnicotinamide was calculated and the sum of the enthalpies of the intermolecular hydrogen bonds N -H center dot center dot center dot O and N -H center dot center dot center dot N, [DHB(N -H center dot center dot center dot O) H + DHB(N -H center dot center dot center dot N) H], formed in the crystalline phase of nicotinamide was also estimated.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8