Single Low-Dose Ionizing Radiation Induces Genotoxicity in Adult Zebrafish and its Non-Irradiated Progeny

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Lemos, J (Author) Other; Neuparth, T (Author) Other; Trigo, M (Author) Other; Costa, P (Author) Other; Vieira, D (Author) Other; Cunha, L (Author) Other; Ponte, F (Author) Other; Costa, PS (Author) Other; Metello, LF (Author) Other; Carvalho, AP (Author) FCUP

Journal

Title: Bulletin of Environmental Contamination and Toxicology

Vol. 98

Pages: 190-195

ISSN: 0007-4861

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00M-GM2

DOI: 10.1007/s00128-016-2006-1

Abstract (EN): This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6