Exploring the Solid-Phase Synthesis of Sulfotyrosine Peptides

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Nuno Vale (Author) FCUP; Veloso, RC (Author) Other; Paula Gomes (Author) FCUP

Journal

Title: European Journal of Organic Chemistry

Vol. 2015

Pages: 7413-7425

ISSN: 1434-193X

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00J-YXP

DOI: 10.1002/ejoc.201500715

Abstract (EN): Tyrosine sulfation is a common post-translational modification operative in many biological processes, including hemostasis and intracellular trafficking. However, the precise structural and functional role of sulfotyrosine residues is not fully understood, so there is a demand for further detailed studies on the role of tyrosine sulfation in biochemical processes. Unfortunately, studies on the biological roles of tyrosine sulfation are hampered by difficulties in gaining access to large quantities of high-purity and homogeneous sulfoproteins and sulfopeptides. This, however, may be addressed by appropriate solid-phase peptide synthesis strategies, and these constitute the core subject of this review. An overview of efficient approaches to the synthesis of sulfopeptides and their associated pros and cons is presented.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13