Blood Flow Visualization and Measurements in Microfluidic Devices Fabricated by a Micromilling Technique

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Jaron Singhal (Author) Other; Diana Pinho (Author) Other; Raquel Lopes (Author) Other; Patricia C. Sousa (Author) FEUP; Valdemar Garcia (Author) Other; Helmut Schütte (Author) Other; Rui Lima (Author) FEUP; Stefan Gassmann (Author) Other

Journal

Title: Micro and Nanosystems

Vol. 7 No. 3

Pages: 148-153

ISSN: 1876-4029

Publisher: Bentham Science

Indexing

Scopus

Other information

DOI: 10.2174/1876402908666160106000332

Abstract (EN): The most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 m and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this work, we show the ability of a micromilling machine to manufacture microchannels down to 30 m and also the ability of a microfluidic device to perform partial separation of red blood cells from plasma. Flow visualization and measurements were performed by using a high-speed video microscopy system. Advantages and limitations of the micromilling fabrication process are also presented.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6