Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Proenca, C (Author) Other; Ribeiro, D (Author) Other; Soares, T (Author) Other; Tome, SM (Author) Other; Silva, AMS (Author) Other; Lima, JLFC (Author) FMUP; Eduarda Fernandes (Author) FFUP; Freitas, M (Author) Other

Journal

Title: Inflammation

Vol. 40

Pages: 1155-1165

ISSN: 0360-3997

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00M-PKH

DOI: 10.1007/s10753-017-0559-8

Abstract (EN): Flavonoids are known to react with neutrophil-generated hypochlorous acid (HOCl) at inflammation loci to form stable mono- and dichlorinated products. Some of these products have been shown to retain or even enhance their inflammatory potential, but further information is required in a broader approach to inflammatory mechanisms. In that sense, we performed an integrated evaluation on the anti-inflammatory potential of a panel of novel chlorinated flavonoids and their parent compounds, in several steps of the complex inflammatory cascade, namely, in the activity of cyclooxygenase (COX)-1 and COX-2, and in the production of cytokines [interleukin (IL)-6, IL-1 beta, tumor necrosis factor (TNF)], and the chemokine, IL-8, as well as in the production of reactive species, using human whole blood as a representative in vitro model, establishing, whenever possible, a structure-activity relationship. Although luteolin was the most active compound, chlorinated flavonoids demonstrated a remarkable pattern of activity for the resolution of the inflammatory processes. Our results demonstrated that 6-chloro-3',4',5,7-tetrahydroxyflavone deserves scientific attention due to its ability to modulate the reactive species and cytokines/chemokine production. In this regard, the therapeutic potential of flavonoids' metabolites, and in this particular case the chlorinated flavonoids, should not be neglected.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11