Chemoprevention of photocarcinogenesis by lycopene

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Ascenso, A (Author) Other; Ribeiro, H (Author) Other; Marques, HC (Author) Other; Oliveira, H (Author) Other; Santos, C (Author) Other; Simoes, S (Author) Other

Journal

Title: Experimental Dermatology

Vol. 23

Pages: 874-878

ISSN: 0906-6705

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00A-1QQ

DOI: 10.1111/exd.12491

Abstract (EN): This review focuses on the photoprotection conferred by lycopene, one of the most potent anti-oxidants. Lycopene has been recently proposed to play a critical role on anticarcinogenic action at different levels. The photoprotective properties of lycopene remain contradictory. Some studies point out a positive and others a negative effect in both in vitro and in vivo models. Currently, researchers recognise that crucial gaps exist in understanding the role of carotenoids as effective modulators of apoptosis, cell cycle dynamics and/or of their in vivo behaviour as cellular anti-oxidants. The development of novel therapeutic strategies for skin disorders depends on our understanding of the molecular mechanism of UV damage on skin cells. The use of several effective phytocompounds, including lycopene, working through preventive and/or corrective pathways in the cell, may be an approach for reducing UV-B-generated damage.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5