Electrochemical behaviour of Venlafaxine and its determination in pharmaceutical products using square wave voltammetry

• Type: Article in International Scientific Journal
• Date: 1999

Authors

Lima, JLFC (Author) FFUP; Loo, DV (Author) Other; Delerue Matos, C (Author) Other; da Silva, ASR (Author) Other

Journal

Title: Farmaco

Vol. 54

Pages: 145-148

ISSN: 0014-827X

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-001-4T9

DOI: 10.1016/s0014-827x(99)00007-5

Abstract (EN): An electrochemical method for the determination of Venlafaxine in pharmaceutical formulations recently available on the European market is described. The electrochemical oxidation of Venlafaxine was studied at a HMDE electrode over a wide pH range (1.9-10.0) of buffered aqueous solutions using different potential sweep techniques. The results obtained showed that the best definition of the analytical signals was found in boric acid/potassium tetrahydroxoborate buffer at pH 8.7 using anodic stripping square wave voltammetry. Recovery trials were performed to assess the accuracy of results and these were compared to those provided by a HPLC technique according to the method described in literature and to the features of the pharmaceutical formulations. A relative deviation of < 0.2% was obtained. With the developed methodology, the limit of detection was 0.124 mg/l.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4