Resumo (PT):
Abstract (EN):
Papillomaviruses induce a range of benign and
malignant lesions in their hosts, including cervical cancer, that is
associated with high-risk human papillomavirus (HPV) types. The
nuclear factor kappa-light-chain-enhancer of activated B-cells
(NF¿B) plays a pivotal role in HPV-infected cells, and its
expression and activity are modulated by several viral
oncoproteins. NF¿B modulation seems to first facilitate viral
persistence and immune evasion, and later to drive tumour
progression, but the many conflicting results and the complexity
of its signaling networks require great prudence while interpreting
the role of NF¿B in papillomaviral lesions. Accordingly, the
pharmacological targeting of the NF¿B pathway in HPV-induced
lesions is a complex and currently unmet challenge. This review
deals with recent findings concerning NF¿B activation in HPVinfected cells, its role in viral persistence, cell transformation and
tumour progression, and with current efforts to target this pathway
for cancer prevention and therapy.
Language:
English
Type (Professor's evaluation):
Scientific
No. of pages:
12