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The NFkB signaling pathway in papillomavirus-induced lesions: Friend or foe?

Title
The NFkB signaling pathway in papillomavirus-induced lesions: Friend or foe?
Type
Article in International Scientific Journal
Year
2016
Authors
Rui M. Gil da Costa
(Author)
FEUP
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Margarida M. S. M. Bastos
(Author)
FEUP
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Rui Medeiros
(Author)
Other
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Paula A. Oliveira
(Author)
Other
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Journal
Title: Anticancer ResearchImported from Authenticus Search for Journal Publications
Pages: 2073-2084
ISSN: 0250-7005
Indexing
Publicação em ISI Web of Science ISI Web of Science
Other information
Authenticus ID: P-010-VFC
Resumo (PT):
Abstract (EN): Papillomaviruses induce a range of benign and malignant lesions in their hosts, including cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The nuclear factor kappa-light-chain-enhancer of activated B-cells (NF¿B) plays a pivotal role in HPV-infected cells, and its expression and activity are modulated by several viral oncoproteins. NF¿B modulation seems to first facilitate viral persistence and immune evasion, and later to drive tumour progression, but the many conflicting results and the complexity of its signaling networks require great prudence while interpreting the role of NF¿B in papillomaviral lesions. Accordingly, the pharmacological targeting of the NF¿B pathway in HPV-induced lesions is a complex and currently unmet challenge. This review deals with recent findings concerning NF¿B activation in HPVinfected cells, its role in viral persistence, cell transformation and tumour progression, and with current efforts to target this pathway for cancer prevention and therapy.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 12
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