Protective effects of Lavandula viridis L'Her extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Patricia Costa (Author) Other; Sarmento, B (Author) Other; Goncalves, S (Author) Other; Romano, A (Author) Other

Journal

Title: Industrial Crops and Products

Vol. 50

Pages: 361-365

ISSN: 0926-6690

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 2 Citations

Associated Projects

LSRE-LCM - Laboratório de Processos de Separação e Reação - Laboratório de Catálise e Materiais

Other information

Authenticus ID: P-008-DAH

DOI: 10.1016/j.indcrop.2013.07.054

Abstract (EN): We investigated the neuroprotective effect of Lavandula viridis extracts (infusion, water:ethanol and methanol) and rosmarinic acid, the major compound present in the extracts, against oxidative damage induced by hydrogen peroxide (H2O2) in A172 human astrocyte cell line regarding the neurotoxic effect, intracellular reactive oxygen species (ROS) production and the activity of the antioxidant enzyme catalase (CAT). We found that L viridis extracts and rosmarinic acid protected A172 astrocytes against H2O2 and reduced intracellular ROS accumulation. Furthermore, the protection effect was not caused by modulation of CAT suggesting that other intracellular mechanisms are involved in the neuroprotective effect. Our results highlight that L viridis extracts and rosmarinic acid have beneficial effects against oxidative damage associated with neurodegenerative diseases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5