C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Rui M. Gil da Costa (Author) FEUP

Journal

Title: Veterinary Journal

Vol. 205 No. 1

Pages: 5-10

ISSN: 1090-0233

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 0 Citations

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Other information

Authenticus ID: P-00G-DQ8

DOI: 10.1016/j.tvjl.2015.05.002

Abstract (EN): Cutaneous roast cell tumours (MCTs) are some of the most common canine neoplasms and their variable and often aggressive biological behaviour makes them particularly challenging for the veterinary practitioner. Over the years, scientists have accumulated a wealth of knowledge on these tumours and developed better prognostic markers and targeted therapies, mostly focused on inhibiting c-kit, a protein that plays a major role in the biopathology of MCTs. Masitinib and toceranib, targeted inhibitors of c-kit and other receptor tyrosine-kinases (RTKs), offer the promise of improving the outcome of patients with aggressive MCTs. Much of the available knowledge on MCTs is dispersed, making it difficult for practitioners to benefit when consulting a pathologist or making therapeutic decisions. This article seeks to bring together current knowledge on the biopathology of MCTs, reviewing prognostic markers and their applications, and the development of c-kit inhibitors in the context of the basic cellular, molecular and pathological features of MCTs. Future perspectives following recent biopathological data and experimental therapeutic approaches are also addressed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6