Immunohistochemical Characterization of 13 Canine Renal Cell Carcinomas

• Type: Article in International Scientific Journal
• Date: 2011

Authors

R. M. Gil da Costa (Author) FEUP; J. P. Oliveira (Author) Other; A. L. Saraiva (Author) Other; F. Seixas (Author) Other; F. Faria (Author) Other; F. Gäertner (Author) Other; M. A. Pires (Author) Other; C. Lopes (Author) Other

Journal

Title: Veterinary Pathology

Vol. 48 No. 2

Pages: 427-432

ISSN: 0300-9858

Publisher: SAGE

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-002-TGM

DOI: 10.1177/0300985810381909

Abstract (EN): Canine renal cell carcinomas (RCCs) are uncommon aggressive tumors that occur mainly in middle-aged male dogs. Their histologic classification bears no relationship with prognosis, and little information is available concerning their immunohistochemical properties. In this retrospective study, formalin-fixed, paraffin-embedded tissues from 13 canine RCCs were retrieved from the archives, classified histologically, and evaluated immunohistochemically. The dogs were 7 males and 6 females (1 spayed) of 10 different breeds, averaging 8 years in age. The tumors were classified as papillary, tubulopapillary, papillary-cystic, solid, or sarcomatoid. All 13 tumors were immunohistochemically positive for uromodulin, 12 for c-KIT, 11 for vimentin, 9 for wide-spectrum-screening cytokeratins, 7 for cytokeratins AE1/AE3 and carcinoembryonic antigen, 4 for cytokeratins CAM 5.2, and 3 for CD10. All 3 solid RCCs expressed vimentin, c-KIT, and carcinoembryonic antigen and were negative for cytokeratins. All 7 papillary and tubulopapillary tumors expressed vimentin; 6 (86%), cytokeratins; and 6 (86%), c-KIT. Both papillary-cystic RCCs were positive for cytokeratins and c-KIT and negative for vimentin. These results indicate that the different histologic types of RCC have characteristic immunohistochemical profiles and that c-KIT may be involved in the pathogenesis of canine RCC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6