Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus)

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Gil da Costa, R. M. (Author) ICBAS; Rema, A (Author) Other; Payo Puente, P (Author) Other; Gaertner, E (Author) Other

Journal

Title: Journal of Comparative Pathology

Vol. 137

Pages: 130-132

ISSN: 0021-9975

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-004-8G5

DOI: 10.1016/j.jcpa.2006.04.006

Abstract (EN): Sebaceons gland carcinoma is a common tumour in male gerbils but, to date, no information is available on its immunohistochemical properties. This report describes the histopathological and immunohistochemical features of such a tumour from a 4.5-year-old male gerbil. The tumour immunoreactivity profile was studied in respect of p53 protein, CEA, EMA, c-erbB-2, cytokeratin (CK) 14 and the CKs detected by AE1/AE3 antibodies (i.e. high molecular weight CKs 1. 2, 3, 4, 5, 6 10 14 1,5 and 16, and low; molecular weight, CKs 7, 8 and 19). The differences observed in p53 and c-erbB-2 immunolabelling between carcinomatous and hyperplastic areas suggest that p53 mutations and amplification of c-erb-B-2 may play a significant role in the oncogenesis of sebaceous gland carcinoma in the gerbil.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3