Estimation of rat mammary tumor volume using caliper and ultrasonography measurements

• Type: Article in International Scientific Journal
• Date: 2013

Authors

A. Faustino Rocha (Author) Other; P. A. Oliveira (Author) Other; J. Pinho Oliveira (Author) Other; C. Teixeira Guedes (Author) Other; R. Soares Maia (Author) Other; R. M. Gil da Costa (Author) FEUP; B. Colaco (Author) Other; M.J. Pires (Author) Other; J. Colaco (Author) Other; R. Ferreira (Author) Other; M. Ginja (Author) Other

Journal

Title: Lab Animal

Vol. 42 No. 6

Pages: 217-224

ISSN: 0093-7355

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 12 Citations

Associated Projects

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Other information

Authenticus ID: P-005-06Q

DOI: 10.1038/laban.254

Abstract (EN): Mammary tumors similar to those observed in women can be induced in rats by intraperitoneal administration of N-methyl-N-nitrosourea. Determining tumor volume is a useful and quantitative way to monitor tumor progression. In this study, the authors measured dimensions of rat mammary tumors using a caliper and using real-time compound B-mode ultrasonography. They then used different formulas to calculate tumor volume from these tumor measurements and compared the calculated tumor volumes with the real tumor volume to identify the formulas that gave the most accurate volume calculations. They found that caliper and ultrasonography measurements were significantly correlated but that tumor volumes calculated using different formulas varied substantially. Mammary tumors seemed to take on an oblate spheroid geometry. The most accurate volume calculations were obtained using the formula V = (W-2 x L)/2 for caliper measurements and the formula V = (4/3) x pi x (L/2) x (L/2) x (D/2) for ultrasonography measurements, where V is tumor volume, W is tumor width, L is tumor length and D is tumor depth.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8