Impact of polymicrobial biofilms in catheter-associated urinary tract infections

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Andreia S. Azevedo (Author) FEUP; Carina Almeida (Author) Other; Luís F. Melo (Author) FEUP; Nuno F. Azevedo (Author) FEUP

Journal

Title: Critical Reviews in Microbiology

Vol. 43 No. 4

Pages: 423-439

ISSN: 1040-841X

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 27 Citations

Associated Projects

Coded-FISH - Desenvolvimento de um novo método de RING FISH codificado por cores: uma ferramenta inovadora para a deteção de patogénios resistentes a antibióticos

Other information

Authenticus ID: P-00M-GHJ

DOI: 10.1080/1040841x.2016.1240656

Abstract (EN): infections are polymicrobial communities, with pathogenic microorganisms (e.g. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and uncommon microorganisms (e.g. Delftia tsuruhatensis, Achromobacter xylosoxidans) frequently co-inhabiting the same urinary catheter. However, little is known about the interactions that occur between different microorganisms and how they impact biofilm formation and infection outcome. This lack of knowledge affects CAUTIs management as uncommon bacteria action can, for instance, influence the rate at which pathogens adhere and grow, as well as affect the overall biofilm resistance to antibiotics. Another relevant aspect is the understanding of factors that drive a single pathogenic bacterium to become prevalent in a polymicrobial community and subsequently cause infection. In this review, a general overview about the IMDs-associated biofilm infections is provided, with an emphasis on the pathophysiology and the microbiome composition of CAUTIs. Based on the available literature, it is clear that more research about the microbiome interaction, mechanisms of biofilm formation and of antimicrobial tolerance of the polymicrobial consortium are required to better understand and treat these infections.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17