Characterization of Neovascular Age-Related Macular Degeneration Patients with Outer Retinal Tubulations

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Faria Correia, F (Author) Other; Barros Pereira, R (Author) Other; Queiros Mendanha, L (Author) Other; Fonseca, S (Author) Other; Mendonca, L (Author) Other; Manuel Falcão (Author) FMUP; Brandao, E (Author) Other; Falcão-Reis F (Author) FMUP; Ângela Carneiro (Author) FMUP

Journal

Title: Ophthalmologica

Vol. 229

Pages: 147-151

ISSN: 0030-3755

Publisher: Karger

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 28 Citations

Other information

Authenticus ID: P-005-3G2

DOI: 10.1159/000346854

Abstract (EN): Purpose: To characterize the neovascular lesions of patients with age-related macular degeneration (AMD) and outer retinal tubulations (ORTs). Methods: A retrospective study of 377 eyes with exudative AMD, submitted to intravitreal anti-angiogenic treatment. Patients were divided into 2 groups according to the presence or absence of ORTs on spectral-domain optical coherence tomography (SD-OCT; group 1 - with ORTs; group 2 - without ORTs). Age, best corrected visual acuity (BCVA), fluorescein angiography characteristics, presence of subretinal fibrosis and subfoveal photoreceptor integrity on SD-OCT were analyzed. Results: Although both groups had a BCVA gain during the follow-up period, initial and final BCVA were lower in group 1 (p = 0.020 and p = 0.042, respectively). There was no statistically significant difference in the BCVA variation between the 2 groups (p = 0.907). Regarding the initial angiographic lesion type, there was a statistically significant difference between the 2 groups (p = 0.008): group 1 had more lesions with a classic component and group 2 had more occult lesions with no classic component. There was a statistically significant difference concerning the loss of subfoveal photoreceptor integrity (p = 0.0007). Conclusions: Even though AMD patients with ORTs were associated with poor visual outcomes, we reported BCVA improvement. AMD patients with a classical component in their lesions are prone to develop ORTs. Copyright (C) 2013 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5