Vitamins B2 and B6 and Genetic Polymorphisms Related to One-Carbon Metabolism as Risk Factors for Gastric Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Eussen, SJPM (Author) Other; Vollset, SE (Author) Other; Hustad, S (Author) Other; Midttun, O (Author) Other; Meyer, K (Author) Other; Fredriksen, A (Author) Other; Ueland, PM (Author) Other; Jenab, M (Author) Other; Slimani, N (Author) Other; Ferrari, P (Author) Other; Agudo, A (Author) Other; Sala, N (Author) Other; Capella, G (Author) Other; Del Giudice, G (Author) Other; Palli, D (Author) Other; Boeing, H (Author) Other; Weikert, C (Author) Other; Bueno de Mesquita, HB (Author) Other; Buechner, FL (Author) Other; Carneiro F (Author) FMUP; Berrino, F (Author) Other; Vineis, P (Author) Other; Tumino, R (Author) Other; Panico, S (Author) Other; Berglund, G (Author) Other; Manjer, J (Author) Other; Stenling, R (Author) Other; Hallmans, G (Author) Other; Martinez, C (Author) Other; Arrizola, L (Author) Other; Barricarte, A (Author) Other; Navarro, C (Author) Other; Rodriguez, L (Author) Other; Bingham, S (Author) Other; Linseisen, J (Author) Other; Kaaks, R (Author) Other; Overvad, K (Author) Other; Tjonneland, A (Author) Other; Peeters, PHM (Author) Other; Numans, ME (Author) Other; Clavel Chapelon, F (Author) Other; Boutron Ruault, MC (Author) Other; Morois, S (Author) Other; Trichopoulou, A (Author) Other; Lund, E (Author) Other; Plebani, M (Author) Other; Riboli, E (Author) Other; Gonzalez, CA (Author) Other

Journal

Title: Cancer Epidemiology Biomarkers and Prevention

Vol. 19 No. 3

Pages: 28-38

ISSN: 1055-9965

Publisher: American Association for Cancer Research

Indexing

ISI Web of Knowledge - 29 Citations

Scopus - 36 Citations

Other information

Authenticus ID: P-003-AAY

DOI: 10.1158/1055-9965.epi-08-1096

Abstract (EN): B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin 132 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for CC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P(trend)) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, <0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with CC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and CC risk, which is borderline significant, and a significant inverse association between vitamin B6 and CC risk. Cancer Epidemiol Biomarkers Prev; 19(1); 28-38. (C)2010 AACR.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11