Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Agudo, A (Author) Other; Sala, N (Author) Other; Pera, G (Author) Other; Capella, G (Author) Other; Berenguer, A (Author) Other; Garcia, N (Author) Other; Palli, D (Author) Other; Boeing, H (Author) Other; Del Giudice, G (Author) Other; Saieva, C (Author) Other; Carneiro F (Author) FMUP; Berrino, F (Author) Other; Sacerdote, C (Author) Other; Tumino, R (Author) Other; Panico, S (Author) Other; Berglund, G (Author) Other; Siman, H (Author) Other; Stenling, R (Author) Other; Hallmans, G (Author) Other; Martinez, C (Author) Other; Bilbao, R (Author) Other; Barricarte, A (Author) Other; Navarro, C (Author) Other; Quiros, JR (Author) Other; Allen, N (Author) Other; Key, T (Author) Other; Bingham, S (Author) Other; Khaw, KT (Author) Other; Linseisen, J (Author) Other; Nagel, G (Author) Other; Overvad, K (Author) Other; Tjonneland, A (Author) Other; Olsen, A (Author) Other; Bueno de Mesquita, HB (Author) Other; Boshuizen, HC (Author) Other; Peeters, PH (Author) Other; Numans, ME (Author) Other; Clavel Chapelon, F (Author) Other; Boutron Ruault, MC (Author) Other; Trichopoulou, A (Author) Other; Lund, E (Author) Other; Offerhaus, J (Author) Other; Jenab, M (Author) Other; Ferrari, P (Author) Other; Norat, T (Author) Other; Riboli, E (Author) Other; Gonzalez, CA (Author) Other

Journal

Title: Cancer Epidemiology Biomarkers and Prevention

Vol. 15

Pages: 2427-2434

ISSN: 1055-9965

Publisher: American Association for Cancer Research

Indexing

ISI Web of Knowledge - 51 Citations

Scopus - 55 Citations

Other information

Authenticus ID: P-004-FKQ

DOI: 10.1158/1055-9965.epi-06-0072

Abstract (EN): Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C > A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G > A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8