Molecular targets and biological modifiers in gastric cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

Carneiro F (Author) FMUP; Oliveira C (Author) FMUP; Marina Leite (Author) Other; Seruca, R (Author) FMUP

Journal

Title: Seminars in Diagnostic Pathology

Vol. 25 No. 4

Pages: 274-287

ISSN: 0740-2570

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 26 Citations

Scopus - 30 Citations

Other information

Authenticus ID: P-003-VCZ

DOI: 10.1053/j.semdp.2008.07.004

Abstract (EN): The overall survival of gastric cancer patients remains poor despite efforts and advances in its prevention, diaposis, and treatment. The development of new therapies is crucial for the effective control of this disease. An increasing number of genetic and epigenetic alterations have been associated with distinct histological types of gastric cancer. In this review, we will discuss the involvement of E-cadherin, EGFR, ERBB2, MMR genes, KRAS, and PIK3CA in the development and progression of gastric cancer and their role as biomarkers or as novel putative targets for therapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14