Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1

• Type: Article in International Scientific Journal
• Date: 1999

Authors

Carvalho, B (Author) Other; Seruca, R (Author) Other; Carneiro F (Author) FMUP; Buys, CHCM (Author) Other; Kok, K (Author) Other

Journal

Title: Genes Chromosomes and Cancer

Vol. 26

Pages: 29-34

ISSN: 1045-2257

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-001-3E3

DOI: 10.1002/(sici)1098-2264(199909)26:1<29::aid-gcc4>3.0.co;2-d

Abstract (EN): Deletions of the long arm of chromosome 6 are a common event in gastric carcinomas. In a previous study, deletion mapping of 6q identified two smallest regions of overlap (SROs) of heterozygous deletions: one interstitial, spanning 12-16 cM, bordered by D6S268 (6q16.3-q21) and ARGI (6q22.3-q23.1), and one distal to IFNGRI (6q23-q24), spanning more than 30 cM. Loss of heterozygosity (LOH) of the interstitial SRO was detected in 50% of informative tumors. We analyzed 60 primary gastric tumors with 19 highly polymorphic markers from 6q16.3-q23.3 to delimit the interstitial SRO further. Of the 50 tumors that were informative for at least one locus, 18 (36%) showed allelic imbalance (Al), The overlap of these cases allowed us to define an SRO of approximately 3 Mb flanked by D6S278 and D6S404. Al or LOH of this region occurs in all histologic types of gastric carcinoma and in early stages of development, indicating that loss of a gene from this region of 6q is a crucial step in a main route of gastric carcinogenesis. For cases with retention of 6q, alternative routes of gastric carcinogenesis may exist. (C) 1999 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6