Radiofrequency ablation for the treatment of gastric dysplasia: a pilot experience in three patients

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Baldaque Silva, F (Author) Other; Cardoso, H (Author) Other; Lopes, J (Author) Other; Carneiro F (Author) FMUP; Macedo G (Author) FMUP

Journal

Title: European Journal of Gastroenterology & Hepatology

Vol. 25

Pages: 863-868

ISSN: 0954-691X

Publisher: Lippincott Williams & Wilkins

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-006-9CM

DOI: 10.1097/meg.0b013e32835f8fa5

Abstract (EN): Different endoscopic techniques such as endoscopic mucosal resection, endoscopic submucosal dissection, argon-plasma coagulation, and photodynamic therapy have been used in the treatment of gastric dysplasia. Radiofrequency ablation (RFA) has become a recognized tool in the treatment of dysplastic Barrett's esophagus, but its use in gastric dysplasia has not yet been studied. We aim to describe three cases of RFA treatment in patients with persistent dysplastic gastric mucosa confirmed by consensus of two expert gastrointestinal pathologists. In each patient, two catheter-based RFA procedures were performed 8 weeks apart in an outpatient setting. Although each patient reported minor epigastric pain after RFA, there were no major complications such as bleeding, perforation, stricture, or the need for hospitalization. Endoscopic follow-up with extensive biopsy sampling 2, 4, 6, 12, and 18 months after the last RFA revealed negative results for dysplasia in all patients. These results suggest that RFA may be considered in the treatment of gastric dysplasia. The confirmation of these data with a large series can lead to a change in the paradigm of gastric dysplasia management. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6