SIGNET RING CELL-CARCINOMA OF THE STOMACH - A MORPHOMETRIC, ULTRASTRUCTURAL, AND DNA CYTOMETRIC STUDY

• Type: Article in International Scientific Journal
• Date: 1992

Authors

Carneiro F (Author) FMUP; MOUTINHORIBEIRO, M (Author) Other; David L (Author) FMUP; SEIXAS, M (Author) Other; SANSONETTY, F (Author) Other; Soares, P (Author) Other; SERRANO, A (Author) Other; Sobrinho Simoes, M (Author) FMUP

Journal

Title: Ultrastructural Pathology

Vol. 16

Pages: 603-614

ISSN: 0191-3123

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-001-P2Z

Abstract (EN): The present study was undertaken to determine whether or not signet ring cell (diffuse, isolated cell) gastric carcinomas display a specific profile at the ultrastructural, morphometric, and DNA cytometric levels. Thirty-two cases of gastric carcinoma and 8 cases of peptic ulcer (control group) were studied with electron microscopy, morphometry, flow cytometry, and image cytometry. Despite the ultrastructural cellular heterogeneity of signet ring cell carcinomas, the neoplastic cells display fairly constant morphometric features: The cellular and nuclear volumes are significantly smaller than those of the other types of gastric carcinomas and closely resemble those of normal foveolar cells. The relatively small size of signet ring cell carcinoma nuclei fits with the high percentage of the cases of this type of gastric carcinoma that are either diploid or nearly diploid. There is a relationship between the infiltrative pattern of growth of gastric carcinoma (regardless of histologic subtype and ultrastructural cell differentiation) and the small size of neoplastic cells and their nuclei.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12