Mixed gastric carcinomas show similar chromosomal aberrations in both their diffuse and glandular components

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Carvalho, B (Author) Other; Buffart, TE (Author) Other; Reis, RM (Author) Other; Mons, T (Author) Other; Moutinho, C (Author) Other; Silva, P (Author) Other; van Grieken, NCT (Author) Other; Grabsch, H (Author) Other; van de Velde, CJH (Author) Other; Ylstra, B (Author) Other; Meijer, GA (Author) Other; Carneiro F (Author) FMUP

Journal

Title: Cellular Oncology

Vol. 28

Pages: 283-294

ISSN: 2211-3428

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-004-P9Q

Abstract (EN): Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number changes throughout the genome. Mixed gastric carcinomas constitute a rare histological entity, containing the two main histological phenotypes (diffuse and intestinal). Very little is known about the underlying mechanisms of phenotypic divergence in these mixed tumours. To the best of our knowledge only E-Cadherin mutations were implicated so far in the divergence of these tumours and nothing is known about the involvement of chromosome copy number changes in the two divergent histological components. In this study, we compared the DNA copy number changes, in the two different components (diffuse and intestinal) of mixed gastric carcinomas by microarray-comparative genomic hybridisation (array CGH). The analysis of 12 mixed gastric carcinomas showed no significant differences in array CGH profiles between the diffuse and intestinal components of mixed carcinomas. This supports the idea that the phenotypic divergence within mixed gastric carcinomas is not caused by DNA chromosomal aberrations.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12