O sistema apelinérgico: papel na fisiologia e patologia humanas e potenciais aplicações terapêuticas

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Ladeiras-Lopes R (Author) FMUP; Ferreira-Martins J (Author) FMUP; Leite-Moreira AF (Author) FMUP

Journal

Title: Arquivos Brasileiros de Cardiologia

Vol. 90 No. 5

Pages: 374-380

ISSN: 0066-782X

Publisher: Sociedad Brasileira De Cardiologia

Indexing

ISI Web of Knowledge - 51 Citations

Scopus - 62 Citations

Other information

Authenticus ID: P-00J-2FM

DOI: 10.1590/s0066-782x2008000500012

Abstract (EN): Apelin is a recently discovered peptide, identified as an endogenous ligand of receptor APJ. Apelin and receptor APJ are expressed in a wide variety of tissues including heart, brain, kidneys and lungs. Their interaction may have relevant pathophysiologic effects in those tissues. In fact, the last decade has been rich in illustrating the possible roles played by apelin in human physiology, namely as a regulating peptide of cardiovascular, hypothalamus-hypophysis, gastrointestinal, and immune systems. The possible involvement of apelin in the pathogenesis of high prevalence conditions and comorbidities - such as hypertension, heart failure, and Diabetes Mellitus Type 2 (T2DM) - rank it as a likely therapeutic target to be investigated in the future. The present paper is an overview of apelin physiologic effects and presents the possible role played by this peptide in the pathogenesis of a number of conditions as well as the therapeutic implications that might, therefore, be investigated.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7