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Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus

Title
Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus
Type
Article in International Scientific Journal
Year
2013
Authors
Bravo, L
(Author)
Other
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Alba Delgado, C
(Author)
Other
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Torres Sanchez, S
(Author)
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Mico, JA
(Author)
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Neto F.L.
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FMUP
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Berrocoso, E
(Author)
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Journal
Title: PainImported from Authenticus Search for Journal Publications
Vol. 154 No. 11
Pages: 2014-2023
ISSN: 0304-3959
Other information
Authenticus ID: P-006-711
Abstract (EN): Stressful experiences seem to negatively influence pain perception through as yet unknown mechanisms. As the noradrenergic locus coeruleus (LC) nucleus coordinates many components of the stress response, as well as nociceptive transmission, we evaluated whether the sensory and affective dimension of chronic neuropathic pain worsens in situations of stress due to adaptive changes of LC neurons. Accordingly, male rats were socially isolated for 5 weeks, and in the last 2 weeks, neuropathic pain was induced by chronic constriction injury. In this situation of stress, chronic pain selectively heightened the animal's aversion to painful experiences (affective pain), as measured in the place escape/avoidance test, although no changes were observed in the sensory dimension of pain. In addition, electrophysiological recordings of LC neurons showed a low tonic but exacerbated nociceptive-evoked activity when the injured paw was stimulated. These changes were accompanied by an increase in tyrosine hydroxylase and gephyrin expression in the LC. Furthermore, intra-LC administration of bicuculline, a c-aminobutyric acid-A receptor antagonist, attenuated the negative affective effects of pain. These data show that changes in the LC are greater than those expected from the simple summation of each independent factor (pain and stress), revealing mechanisms through which stressors may exacerbate pain perception without affecting the sensorial dimension.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 10
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