ACTH Induces ERK 1/2 Activation in Rat Adrenal Primary Cultures

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

Rodrigues, AR (Author) Other; Gouveia, Alexandra (Author) FCNAUP; J Ferreira (Author) FMUP; Almeida, Henrique (Author) FMUP

Journal

Title: Microscopy and Microanalysis

Vol. 14 No. S3

Pages: 101-102

ISSN: 1431-9276

Publisher: Cambridge University Press

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-003-WQ6

DOI: 10.1017/s1431927608089526

Abstract (EN): Adrenocorticotropic hormone (ACTH) is the most potent stimulator of adrenal cortex, acting through the Melanocortin-2 receptor (MC2R). ACTH induces secretion of steroid hormones, critical for the normal stress response and plays also an important role on cell proliferation and differentiation. MC2R is a classical G-Protein coupled receptor (GPCR), thus activating Protein Kinase A (PKA). However, many studies suggested a cross-talk between different signalling pathways and a more complex intracellular network. In fact, in adrenocortical Y1 tumour cell line, ACTH may activate Extracellular Regulated Kinases 1/2 (ERK 1/2), which belong to the Mitogen-Activated Protein Kinases (MAPKs) family. In addition, this pathway was implicated in in vivo proliferation and steroidogenesis as shown by our group. In order to further explore and clarify ACTH signalling mechanisms, we made the present work to establish a model of primary cultures of rat adrenal cells. © 2008 Microscopy Society of America.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 2