Basal cell carcinoma of the skin (part 1): epidemiology, pathology and genetic syndromes

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Correia de Sa, TRC (Author) Other; Silva, R (Author) Other; Lopes, JM (Author) FMUP

Journal

Title: Future Oncology

Vol. 11

Pages: 3011-3021

ISSN: 1479-6694

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 33 Citations

Other information

Authenticus ID: P-00G-WGB

DOI: 10.2217/fon.15.246

Abstract (EN): Basal cell carcinoma (BCC) is the most common skin cancer worldwide with increasing incidence, but difficult to assess due to the current under registration practice. Despite the low mortality rate, BCC is a cause of great morbidity and an economic burden to health services. There are several risk factors that increase the risk of BCC and partly explain its incidence. Low-penetrance susceptibility alleles, as well as genetic alterations in signaling pathways, namely SHH pathway, also contribute to the carcinogenesis. BCC associate with several genetic syndromes, of which basal cell nevus syndrome is the most common.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11