Hypertension and angiogenesis in the aging kidney: A review

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Duarte, D (Author) FMUP; Santos Araujo, C (Author) Other; Leite-Moreira AF (Author) FMUP

Journal

Title: Archives of Gerontology and Geriatrics

Vol. 52 No. 3

Pages: E93-E102

ISSN: 0167-4943

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-002-S8A

DOI: 10.1016/j.archger.2010.11.032

Abstract (EN): With advanced aging, main components of the kidney are altered, including blood vessels, glomeruli and tubulointerstitium. Disruption in these 3 elements is interconnected and associated with several modifications, such as loss of kidney mass and systemic, metabolic and immunologic diseases. In this review we focus on renal blood vessels, the key role of hypertension and angiogenesis in the elderly kidney, the hemodynamic and molecular mechanisms underlying this aging process and the main factors involved. So far, the present data suggests a strong association between renal disease and hypertension and the impairment of regulatory mechanisms, such as angiogenesis in the aging kidney. The endothelium is a key player in vascular control and appears to be also disrupted in many compensatory functions (i.e., vasodilation). Perspectives for the management of the dysfunctional aging kidney are also addressed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10