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Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators

Title
Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators
Type
Article in International Scientific Journal
Year
2016
Authors
Marta R Couto
(Author)
FMUP
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Vale, L
(Author)
FMUP
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Carvalho, J
(Author)
Other
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Bettencourt P
(Author)
FMUP
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Albino Teixeira, A
(Author)
FMUP
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Sousa, T
(Author)
FMUP
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Journal
Title: Current Drug TargetsImported from Authenticus Search for Journal Publications
Vol. 17
Pages: 1206-1223
ISSN: 1389-4501
Publisher: Bentham Science
Other information
Authenticus ID: P-00M-8CN
Abstract (EN): Inflammation is an important pathogenic mechanism in chronic heart failure (HF). The perpetuation of the inflammatory response in this syndrome may result either from excessive activation of proinflammatory cascades or disturbances in the resolution of inflammation. However, although cardiovascular research has extensively investigated the proinflammatory processes involved in chronic HF pathophysiology, the mechanisms responsible for inflammation resolution in this disease remain largely disregarded. The resolving response is currently considered an active process involving specific effectors that limit the progression of inflammation and promote tissue regeneration. This article aims at reviewing the major classes of lipid mediators of inflammation resolution, their cardiovascular, metabolic and renal protective effects that might putatively delay the onset and progression of chronic HF, and their therapeutic modulation. Furthermore, it also aims to emphasize the importance of adopting therapeutic strategies that stimulate the resolution of inflammation in chronic HF.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 18
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