OPIATES MODIFY INDUCTION OF C-FOS PROTOONCOGENE IN THE SPINAL-CORD OF THE RAT FOLLOWING NOXIOUS-STIMULATION

• Type: Article in International Scientific Journal
• Date: 1990

Authors

TOLLE, TR (Author) Other; Castro-Lopes J.M. (Author) FMUP; COIMBRA, A (Author) Other; ZIEGLGANSBERGER, W (Author) Other

Journal

Title: Neuroscience Letters

Vol. 111

Pages: 46-51

ISSN: 0304-3940

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 111 Citations

Scopus - 107 Citations

Other information

Authenticus ID: P-001-RX3

DOI: 10.1016/0304-3940(90)90342-7

Abstract (EN): The expression of the proto-oncogene c-fos in neurons of the spinal cord dorsal horn of the rat following noxious thermal stimulation was compared in morphine- and ketamine-treated animals. Intravenous injection of morphine reduced the number of c-fos-positive neurons by up to 85% in laminae III-VI and X. This effect was dose dependent and naloxone reversible. The non-competitive N-methyl-d-asparate (NMDA) antagonist ketamine had no effect. The present data show that morphine suppresses the induction of c-fos. A block of Ca2+ influx through voltage- and ligand (NMDA)-gated channels does not influence c-fos protein synthesis in the dorsal horn of the spinal cord in vivo. © 1990.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6