Preparation of albumin preferential surfaces on poly(vinyl chloride) membranes via surface self-segregation

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Ji, J (Author) Other; Feng, LX (Author) Other; Shen, JC (Author) Other; Mário Adolfo Barbosa (Author) FEUP

Journal

Title: Journal of Biomedical Materials Research

Vol. 61

Pages: 252-259

ISSN: 0021-9304

Publisher: Heterocorporation

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-000-NGB

DOI: 10.1002/jbm.10187

Abstract (EN): Poly(vinyl chlorides) -graft- [omega-stearylpoly(ethylene oxide)] (PVC-g-SPEO), which has a poly(vinyl chloride) (PVC) backbone, poly(ethylene oxide) (PEO) side chain, and stearyl end groups, has been synthesized. Self-organizing blends of the amphiphilic comb polymer in poly(vinyl chlorides) have been examined as a means to create albumin preferential surfaces on polymer films. X-ray photoelectron spectroscopy (XPS) analysis indicates substantial surface segregation of the PVC-g-SPEO. A surface concentration of 59.9 EO wt % is achieved by the solution casting and heat treatment of a film with a bulk concentration of only 3.78 EO wt%. In the aqueous environment, the surface rearrangement of PVC-g-SPEO/PVC blend film is limited and presents a high interfacial energy and high depolar component of interfacial energy due to the "tail-like" SPEO side chain. Protein adsorption tests confirm that PVC-g-SPEO/PVC blend films absorb high levels of albumin and dramatically resist fibrinogen adsorption. Surfaces to attract and reversibly bind albumin, which might diminish the occurrence of thrombosis, inflammation, and infection, are developed by self-organizing blends of the amphiphilic comb polymer in poly(vinyl chlorides). (C) 2002 Wiley Periodicals, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8