Microgravity effects on ventricular response to heart rate changes

• Type: Article in International Conference Proceedings Book
• Date: 2012

Authors

Bolea, J (Author) Other; Caiani, EG (Author) Other; Pueyo, E (Author) Other; Laguna, P (Author) Other; Almeida, R (Author) FCUP

Conference proceedings International

Title: 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

Pages: 3424-3427

34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS)

San Diego, CA, AUG 28-SEP 01, 2012

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-008-7WM

DOI: 10.1109/embc.2012.6346701

Abstract (EN): The effect of simulated microgravity on ventricular repolarization (VR) has been evaluated on healthy volunteers by a 5-day Head Down (-6 degrees) Bed Rest (HDBR) maneuver. QT to RR and QT(p) (measured until the peak of the T wave) to RR hystereses have been measured during a tilt table test, and differences between them have been studied to better understand possible changes in the final part of the repolarization. To characterize the hystereses, two indices have been computed: M-90, quantifying adaptation lag in beats, and alpha evaluating the slope of parabolic regression fitting. Significant differences between QT and QT(p) were found before, but not after HDBR. Specifically, before HDBR was considerable lower for QT(p) than for QT, while alpha was significantly higher. After HDBR, M-90 and alpha took essentially the same values for QT and QT(p). This fact evidenced the different effect of HDBR on QT to RR and QT(p) to RR adaptations, and suggest HDBR could lead to an impairment in ventricular repolarization dispersion.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4