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Telomerase Activation in Hematological Malignancies

Title
Telomerase Activation in Hematological Malignancies
Type
Another Publication in an International Scientific Journal
Year
2016
Authors
Ropio, J
(Author)
Other
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Merlio, JP
(Author)
Other
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Soares, P
(Author)
FMUP
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Chevret, E
(Author)
Other
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Journal
Title: GenesImported from Authenticus Search for Journal Publications
Vol. 7
Final page: 61
ISSN: 2073-4425
Publisher: MDPI
Other information
Authenticus ID: P-00K-WHH
Abstract (EN): Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 13
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