CC chemokine receptor polymorphism CCR5 Delta 32 in Portuguese Behcet's disease patients

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Bettencourt, A (Author) Other; Leal, B (Author) Other; Carvalho, C (Author) Other; Oliveira, R (Author) Other; Martins Silva, AM (Author) Other; Vaz Patto, JV (Author) Other; Bastos, M (Author) Other; Costa, L (Author) Other; costa, pp (Author) ICBAS; Vasconcelos, C (Author) Other; Correia, J (Author) Other; Silva, BM (Author) Other

Journal

Title: Clinical and Experimental Rheumatology

Vol. 32

Pages: S72-S74

ISSN: 0392-856X

Publisher: Pacini Editore SpA

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-009-V9M

Abstract (EN): Objective. To investigate whether CCR5 deletion is associated with susceptibility to Behcet's disease (BD) in a Portuguese population. Methods. A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5 Delta 32 polymorphisms was performed using polymerase chain reaction product sizing. Results. No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences. Conclusion. These results indicate that CCR5 Delta 32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3