MUC1 expression in canine malignant mammary tumours and relationship to clinicopathological features

• Type: Article in International Scientific Journal
• Date: 2009

Authors

de Oliveira, JT (Author) Other; Pinho, SS (Author) Other; Augusto Matos (Author) ICBAS; Hespanhol V (Author) FMUP; Celso Reis (Author) ICBAS; Gaertner, F (Author) Other

Journal

Title: Veterinary Journal

Vol. 182

Pages: 491-493

ISSN: 1090-0233

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 17 Citations

Other information

Authenticus ID: P-003-E8W

DOI: 10.1016/j.tvjl.2008.09.007

Abstract (EN): Mucin-1 (MUC1) is over-expressed in human breast carcinomas and is linked to a poorer prognosis in this study. MUC1 expression in 32 spontaneous canine malignant mammary tumours was characterised in relation to histological type. mode of growth, grade, lymph node metastases and distant metastases All tumours exhibited immunostaining for MUC1. In the normal canine mammary gland, MUC1 was expressed mainly in the apical cellular membrane, while in carcinomas MUC1 was detected in the cytoplasm only (56.3%) or in the cytoplasm with membrane accentuation (43.7%) There was a significant association between development of distant metastases and MUC1 over-expression (P = 0 03), but no association with histological type, histological grade. mode of growth or lymph node metastasis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3