Canine tumors: a spontaneous animal model of human carcinogenesis

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Pinho, SS (Author) Other; Carvalho, S (Author) Other; Cabral, J (Author) Other; Celso Reis (Author) ICBAS; Gaertner, F (Author) Other

Journal

Title: Translational Research

Vol. 159

Pages: 165-172

ISSN: 1931-5244

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 149 Citations

Scopus - 158 Citations

Other information

Authenticus ID: P-002-CRP

DOI: 10.1016/j.trsl.2011.11.005

Abstract (EN): The enormous biologic complexity of human cancer has stimulated the development of more appropriate experimental models that could resemble in a natural and spontaneous manner the physiopathologic aspects of cancer biology. Companion animals have many desired characteristics that fill the gap between in vitro and in vivo studies, and these characteristics have proven to be important in understanding many complex molecular aspects of human cancer. Spontaneous tumors in dogs share a wide variety of epidemiologic, biologic, and clinical features with human cancer, which makes this animal model both attractive and underused in oncology research. In this review, we summarize the importance of naturally occurring canine tumors as valuable tools for studying numerous aspects of human cancer as well as the potential use of this animal model for the development of new cancer treatments. We address specifically the use of canine mammary tumors as an increasingly powerful model to study human breast cancer. (Translational Research 2012;159:165-172)

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8