Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Ferreira, JA (Author) Other; Videira, PA (Author) Other; Lima, L (Author) Other; Pereira, S (Author) Other; Silva, M (Author) Other; Carrascal, M (Author) Other; Seuerino, PF (Author) Other; Fernandes, E (Author) Other; Almeida, A (Author) Other; Costa, C (Author) Other; Vitorino, R (Author) Other; Amaro, T (Author) Other; Oliveira, MJ (Author) FCUP; Celso Reis (Author) ICBAS; Dall'Olio, F (Author) Other; Amado, F (Author) Other; Lucio Lara Santos (Author) ICBAS

Journal

Title: Molecular Oncology

Vol. 7

Pages: 719-731

ISSN: 1574-7891

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 62 Citations

Scopus - 62 Citations

Other information

Authenticus ID: P-006-ADA

DOI: 10.1016/j.molonc.2013.03.001

Abstract (EN): Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GaINAc.I, its major biosynthetic enzyme. The stable expression of ST6GaINAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13