The influence of two different drug infusion profiles on the pharmacodynamics model performance

• Type: Article in International Conference Proceedings Book
• Date: 2015

Authors

Ferreira, AL (Author) Other; Nunes, CS (Author) Other; Joaquim Gabriel Magalhães Mendes (Author) FEUP; Amorim, P (Author) Other

Conference proceedings International

Title: WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, 2015, VOLS 1 AND 2

Pages: 874-880

World Congress on Medical Physics and Biomedical Engineering

Toronto, CANADA, JUN 07-12, 2015

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00G-QTW

DOI: 10.1007/978-3-319-19387-8_214

Abstract (EN): To model the effect of anesthetic drugs on the Bispectral Index (BIS) of the EEG is of great importance for a reliable predictive response model during surgery. In this study, the impact of using two different drug infusion profiles in a pharmacodynamics interaction model was studied and the methods were compared with respect to their performance. Clinical data of 22 patients were considered. The interaction model was optimized per patient using nonlinear least squares during the induction of anesthesia, and tested for prediction abilities of test patients. In the optimization phase, all models could follow the BIS trend with errors not significantly different from zero. In the test data the choice of drug infusion profile proved to have a significant impact, showing that the performance is greatly influenced by the interaction. Results also show a time delay between the BIS signal and the Modeled BIS in both groups. This delay corresponds to a delay in the dynamics of the patient and could be related to the delay in BIS processing time. This work is an important step to predict the effect of anesthetic drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7