FACILITATION OF [H-3] ACH RELEASE BY FORSKOLIN DEPENDS ON A(2)-ADENOSINE RECEPTOR ACTIVATION

• Type: Article in International Scientific Journal
• Date: 1993

Authors

Paulo Correia de Sá (Author) Other; RIBEIRO, JA (Author) Other

Journal

Title: Neuroscience Letters

Vol. 151

Pages: 21-24

ISSN: 0304-3940

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-001-N99

DOI: 10.1016/0304-3940(93)90035-j

Abstract (EN): The effect of forskolin (FSK) on [H-3]-acetylcholine release ([H-3]-ACh) from the phrenic motor nerve terminals, and its modification by adenosine deaminase (ADA), by the A2-adenosine receptor agonist 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamide adenosine (CGS 21680C), by the A1-adenosine receptor agonist R-N6-phenylisopropyl adenosine (R-PIA), by the A2-antagonist N-(2-(dimethylamino)-ethyl)-N-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purine-8-yl)-benzene sulphonamide (PD 115,199), and by the A1-antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) were studied on the rat phrenic-hemidiaphragm preparation. It is concluded that the excitatory effect of FSK on evoked [H-3]-ACh release depends on tonic A2-adenosine receptor activation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4