Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome
Publication

Publications

Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome

Title
Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome
Type
Article in International Scientific Journal
Year
2013
Authors
Silva Ramos, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Silva, I
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Oliveira, O
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Ferreira, S
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Reis, MJ
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Oliveira, JC
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Paulo Correia de Sá
(Author)
ICBAS
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Journal
Title: PLoS ONEImported from Authenticus Search for Journal Publications
Vol. 8 No. 1
Final page: e64696
ISSN: 1932-6203
Other information
Authenticus ID: P-005-0MK
Abstract (EN): Background: Nowadays, there is a considerable bulk of evidence showing that ATP has a prominent role in the regulation of human urinary bladder function and in the pathophysiology of detrusor overactivity. ATP mediates nonadrenergic-noncholinergic detrusor contractions in overactive bladders. In vitro studies have demonstrated that uroepithelial cells and cholinergic nerves from overactive human bladder samples (OAB) release more ATP than controls. Here, we compared the urinary ATP concentration in samples collected non-invasively from OAB women with detrusor overactivity and age-matched controls. Methods: Patients with neurologic diseases, history of malignancy, urinary tract infections or renal impairment (creatinine clearance <70 ml/min) were excluded. All patients completed a 3-day voiding diary, a 24 h urine collection and blood sampling to evaluate creatinine clearance. Urine samples collected during voluntary voids were immediately freeze-preserved for ATP determination by the luciferin-luciferase bioluminescence assay; for comparison purposes, samples were also tested for urinary nerve growth factor (NGF) by ELISA. Results: The urinary content of ATP, but not of NGF, normalized to patients' urine creatinine levels (ATP/Cr) or urinary volume (ATP. Vol) were significantly (P<0.05) higher in OAB women with detrusor overactivity (n = 34) than in healthy controls (n = 30). Significant differences between the two groups were still observed by boosting urinary ATP/Cr content after water intake, but these were not detected for NGF/Cr. In OAB patients, urinary ATP/Cr levels correlated inversely with mean voided volumes determined in a 3-day voiding diary. Conclusion: A high area under the receiver operator characteristics (ROC) curve (0.741; 95% CI 0.62-0.86; P<0.001) is consistent with urinary ATP/Cr being a highly sensitive dynamic biomarker for assessing detrusor overactivity in women with OAB syndrome.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 10
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

Reliability in long-term clinical studies of disease-modifying therapies for relapsing-remitting multiple sclerosis: A systematic review (2020)
Another Publication in an International Scientific Journal
Lucchetta, RC; Leonart, LP; Goncalves, MVM; Becker, J; Pontarolo, R; Fernandez Llimos, F; Wiens, A
Questionnaires measuring movement behaviours in adults and older adults: Content description and measurement properties. A systematic review (2022)
Another Publication in an International Scientific Journal
Rodrigues, B; Encantado, J; Carraca, E; Sousa Sa, E; Lopes, L; Cliff, D; Mendes, R; Silva, MN; Godinho, C; Santos, R
Mapping the characteristics of network meta-analyses on drug therapy: A systematic review (2018)
Another Publication in an International Scientific Journal
Tonin, FS; Steimbach, LM; Mendes, AM; Borba, HH; Pontarolo, R; Fernandez Llimos, F
Fecal microbiota transplantation in inflammatory bowel disease patients: A systematic review and meta-analysis (2020)
Another Publication in an International Scientific Journal
Caldeira, LD; Borba, HH; Tonin, FS; Wiens, A; Fernandez Llimos, F; Pontarolo, R
Establishing the criterion validity of self-report measures of adherence in hemodialysis through associations with clinical biomarkers: A systematic review and meta-analysis (2022)
Another Publication in an International Scientific Journal
Sousa, H; Ribeiro, O; Costa, E; Christensen, AJ; Figueiredo, D

See all (436)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-25 at 13:07:23 | Privacy Policy | Personal Data Protection Policy | Whistleblowing