ULTRASTRUCTURAL AND ELECTRON IMMUNOHISTOCHEMICAL FEATURES OF MEDULLARY-THYROID CARCINOMA

• Type: Article in International Scientific Journal
• Date: 1989

Authors

HOLM, R (Author) Other; FARRANTS, GW (Author) Other; NESLAND, JM (Author) Other; Sobrinho Simoes, M (Author) FMUP; JORGENSEN, OG (Author) Other; JOHANNESSEN, JV (Author) Other

Journal

Title: Virchows Archiv - A Pathological Anatomy and Histopathology

Vol. 414

Pages: 375-384

ISSN: 0174-7398

Publisher: Springer

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-001-T1G

DOI: 10.1007/bf00718620

Abstract (EN): An ultrastructural study, both morphological and immunohistochemical, has been carried out on eight thyroglobulin-positive and nine thyroglobulin-negative medullary carcinomas of the thyroid. The morphometric analysis of granule size showed that all tumours contained cells with small granules and cells with medium size granules, whereas eight tumours had additional cells with large granules. The small granules had an electron dense core, while the medium and large sized granules were both pale-cored and dense-cored. The cells with small, medium or large secretory granules were all immunoreactive for calcitonin and CGRP. No ultrastructural differences were observed between thyroglobulin-positive and thyroglobulin-negative cases of medullary carcinoma of the thyroid. © 1989 Springer-Verlag.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10