Expression of stratified epithelial-type cytokeratins in hyalinizing trabecular adenomas supports their relationship with papillary carcinomas of the thyroid

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Fonseca E (Author) Other; Nesland, JM (Author) Other; Sobrinho Simoes, M (Author) FMUP

Journal

Title: Histopathology

Vol. 31

Pages: 330-335

ISSN: 0309-0167

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 50 Citations

Scopus - 60 Citations

Other information

Authenticus ID: P-001-AJS

DOI: 10.1046/j.1365-2559.1997.2720878.x

Abstract (EN): Aim: To evaluate the cytokeratin patter of expression of hyalinizing trabecular adenomas and to verify whether or not these tumours, that share morphological features with papillary carcinomas, present the stratified epithelial-type cytokeratins commonly found in ordinary papillary carcinomas. Methods and results: This study consisted of the immunohistochemical detection of simple and stratified epithelial type cytokeratin filaments in a series of six hyalinizing trabecular adenomas, three papillary carcinomas with a trabecular growth pattern and two carcinomas combining hyalinizing trabecular and papillary patterns. Simple epithelial-type cytokeratins 7, 8, 18 and 19 were found in every case. Expression of the stratified epithelial-type cytokeratins 1, 5/6 and/or 13 was detected in four hyalinizing trabecular adenomas. Conclusion: Based on this, as well as on the cytological features and on the frequent co-occurrence of hyalinizing trabecular adenoma and papillary carcinoma, we suggest that the former lesion may be considered a peculiar encapsulated variant of papillary carcinoma.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6