Carbohydrate antigens as oncofetal antigens in papillary carcinoma of the thyroid gland

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Fonseca E (Author) Other; Castanhas, S (Author) Other; Sobrinho Simoes, M (Author) FMUP

Journal

Title: Endocrine Pathology

Vol. 8

Pages: 301-303

ISSN: 1046-3976

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-001-A9H

DOI: 10.1007/bf02739932

Abstract (EN): The expression of simple mucin-type antigens, Lewis type-1 antigens, and Lewis type-2-related antigens was evaluated by immunohistochemistry in a series of nine fetal thyroid glands. The aim of the study was to establish whether the previously reported expression of carbohydrate antigens in thyroid carcinomas represents a "de novo" expression or a form of the so-called oncofetal expression. We have detected simple mucin-type antigens and Lewis type-2-related antigens in fetal thyroid tissue. Lewis type-1 antigens were not found. Taking the results of this study together with those previously reported, we conclude that the presence of Lewis type 1 antigens in thyroid carcinomas appears to be a "de novo" expression, whereas the constant and strong expression of simple mucin-type antigens and Lewis type-2-related antigens represents a reexpression (oncofetal expression) of antigens already present during fetal life.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3