Small-Cell (Basaloid) Thyroid Carcinoma: A Neoplasm With a Solid Cell Nest Histogenesis?

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Cruz, J (Author) Other; Catarina Eloy (Author) FMDUP; Araguees, JM (Author) Other; Vinagre, J (Author) Other; Sobrinho Simoes, M (Author) FMUP

Journal

Title: International Journal of Surgical Pathology

Vol. 19

Pages: 620-626

ISSN: 1066-8969

Publisher: SAGE

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-002-KS3

DOI: 10.1177/1066896911405320

Abstract (EN): In the past, undifferentiated (anaplastic) carcinoma of the thyroid included a small-cell variant with either a diffuse or a compact morphology. After the mid-1980s, with the advance of immunohistochemistry, almost all those rare tumors with the former characteristic were reclassified as low-grade lymphomas and those with the latter characteristic as small-cell variants of medullary carcinoma and poorly differentiated ("insular") carcinoma. Since then, no primary thyroid small-cell carcinoma has been reported in the literature, with the exception of a case of a small-cell (neuroendocrine) carcinoma, an exceedingly rare neoplasm akin to medullary carcinoma, with expression of neuroendocrine markers but lacking calcitonin immunoreactivity. Here, the authors report a primary small-cell carcinoma of the thyroid displaying a basaloid appearance and lacking any signs of neuroendocrine or C-cell differentiation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7