Thalidomide-induced acute cholestatic hepatitis: Case report and review of the literature

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Vilas Boas, F (Author) Other; Goncalves, R (Author) Other; Sobrinho Simoes, M (Author) FMUP; Lopes, J (Author) Other; Macedo G (Author) FMUP

Journal

Title: Gastroenterologia y Hepatologia

Vol. 35

Pages: 560-566

ISSN: 0210-5705

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-002-4XF

DOI: 10.1016/j.gastrohep.2012.05.007

Abstract (EN): Drug-induced liver injury (DILI) is a leading cause of liver failure and an important safety issue in drug development. Thalidomide is nowadays used for the treatment of several conditions including multiple myeloma (MM). Several adverse effects have been described but liver toxicity was seldom reported. We describe a case of thalidomide-induced hepatitis in a man treated for MM. The clinical setting and temporal association between the start of the drug and liver injury allowed the assumption of the causative role of thalidomide. As its clinical indications expand we wish to increase awareness of a new potential side effect of thalidomide. A short review on thalidomide-induced liver injury is also presented.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7