HURTHLE-CELL LESIONS OF THE THYROID - A COMBINED STUDY USING TRANSMISSION ELECTRON-MICROSCOPY, SCANNING ELECTRON-MICROSCOPY, AND IMMUNOCYTOCHEMISTRY

• Type: Article in International Scientific Journal
• Date: 1985

Authors

NESLAND, JM (Author) Other; Sobrinho Simoes, M (Author) FMUP; HOLM, R (Author) Other; SAMBADE, MC (Author) Other; JOHANNESSEN, JV (Author) Other

Journal

Title: Ultrastructural Pathology

Vol. 8

Pages: 269-290

ISSN: 0191-3123

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 65 Citations

Scopus - 55 Citations

Other information

Authenticus ID: P-001-WM7

Abstract (EN): Hurthle cell transformation found in 2 nodular goiters, 2 cases of Hashimoto's thyroiditis, 4 follicular adenomas, 3 follicular carcinomas, 2 papillary carcinomas and 1 anaplastic carcinoma were studied by transmission electron microscopy, scanning electron microscopy and immunocytochemistry. Ultrastructural features of Hurthle cells were identical in non-neoplastic and neoplastic lesions. Cells crammed with mitochondria, showing abnormalities in size, shape and content were prominent in most cases. The presence of distinct smooth-surfaced cells interspersed with cells with many microvilli is almost a pathognomonic scanning electron microscopic feature of benign and malignant Hurthle cell lesions. Most Hurthle cells stained positively for thyroglobulin in all cases, but no immunoreactivity for CEA and calcitonin was found.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22