LECTIN HISTOCHEMISTRY AND ULTRASTRUCTURE OF MEDULLARY CARCINOMA OF THE THYROID-GLAND

• Type: Article in International Scientific Journal
• Date: 1990

Authors

Sobrinho Simoes, M (Author) FMUP; SAMBADE, C (Author) Other; NESLAND, JM (Author) Other; HOLM, R (Author) Other; DAMJANOV, I (Author) Other

Journal

Title: Archives of Pathology and Laboratory Medicine

Vol. 114

Pages: 369-375

ISSN: 0003-9985

Publisher: American Medical Association

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-001-RVG

Abstract (EN): Lectin histochemistry and electron microscopy were used to study a series of 13 solid or microacinar medullary carcinomas of the thyroid (MCTs) and compare them with four follicular MCTs and other forms of thyroid cancer. Lectin histochemmistry was not found to be of diagnostic value, since the MCT did not display any distinct lectin-binding pattern. This approach demonstrated that all MCTs, irrespective of their histologic appearance, consist of polarized cells, arranged into microfollicles that can be demonstrated readily by electron microscopy. We conclude that all MCTs form follicles, some visible by light microscopy, while others are submicroscopic and apparent only on histochemical staining. Because of the histochemical and ultrastructural similarities between solid MCTs and tumors with a follicular pattern, the latter should be considered a distinct variant of C-cell neoplasia.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7