GLOMERULAR ACID-PHOSPHATASE ACTIVITY IN RAT NEPHROTOXIC SERUM NEPHRITIS

• Type: Article in International Scientific Journal
• Date: 1977

Authors

Sobrinho Simoes, M (Author) FMUP; FARIA, V (Author) Other; ALBUQUERQUE, R (Author) Other

Journal

Title: Journal of Submicroscopic Cytology and Pathology

Vol. 9

Pages: 339-345

ISSN: 1122-9497

Publisher: N I E Nuova Immagine Editrice

Indexing

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Other information

Authenticus ID: P-001-Z1P

Abstract (EN): Slide and ultrastructural histochemical methods were used in the study of glomerular acid phosphatase activity of rats that were given nephrotoxic serum and proteinuria was used to evaluate the progression of the renal disease. Rats that had received two or more doses of nephrotoxic serum showed a remarkable increase in glomerular acid phosphatase activity which was mainly localized in lysosomes of mesangial cells, although some acid phosphatase positive lysosomes could also be found in the other types of glomerular cells. The third dose of the serum did not produce any further increase in glomerular acid phosphatase activity, but caused the appearance of a greater number of mesangial cells with signals of regressive changes and significantly aggravated the evolution of the renal disease. It is suggested that this worse progression of the renal disease might depend upon the saturation of mesangial cells ability to react to glomerular damage and that mesangial acid phosphatase activity may be used as an indicator of the mesangial cell injury.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7